Our overriding obsession is committing to great targets for drug discovery. We give equal attention to the questions of disease dependency and therapeutic index (i.e., the difference between efficacious and toxic dose). We will not ask you, after the fact, to salvage a borderline project with positively biased experiments, biomarker hunting, or empiric combination work. Biologists at Treeline are the critical gatekeepers of our pipeline, from the moment of program inception.

Despite the emergence of exciting new modalities (e.g., cell and gene therapy, complex biologics, etc.) we believe that small molecule medicinal chemistry will remain the backbone of the therapeutic armamentarium. We place high probability bets to focus on molecular targets amenable to traditional chemistry approaches, with increasingly heavy contributions from newer modalities. The chemists we recruit to Treeline are diligent, mindful of ADME as well as target engagement, and open-minded to advances in their own and adjacent fields. You won’t be replaced by a computer; rather, you will rely on computers to help design great drug candidates instead of taking a heads down, brute force approach.

In a world of hype and infinite use cases for computer-enabled drug discovery, our team stays focused on the highest probability applications of computational technology. We recognize that target selection, medicinal chemistry and clinical development are fundamentally too complicated to outsource to CROs and SABs. Computational approaches informed and refined by project specific, real-world experimental data are the most powerful. By joining a balanced and inter-disciplinary team, the north star of your career will move from the “use case” to clinical proof of efficacy.

Our focus on protein structure and function is unrelenting. Whether you specialize in X-ray crystallography, SPR, biochemistry, NMR, novel assay development, mass spec, or scaled protein production, you will join a team that is passionate about pushing the envelope. Your assays and data will provide the oxygen for our medicinal chemistry and medicine design teams. We rely on you to match the right experimental system to the right question, and to help us prepare the major advances likely to come, but not guaranteed, by cryo-EM and emerging atomic biophysical technologies.