Associate Director/Director, Protein and Assay Informatics
About the role
In your role as Associate Director/Director, Protein and Assay Informatics, you will help architect an integrated scientific data platform for Treeline Biosciences, with an initial sharp focus on biochemical/biophysical assay, protein reagent, macromolecular structure, and in vivo data. You will drive critical research decisions by enabling the design and implementation of integrated data pipelines to enable Treeline to answer most difficult drug discovery questions. You will closely collaborate with scientists from all disciplines to streamline these data pipelines to reduce time-to-answer core research questions involving biology, pharmacology, drug metabolism and pharmacokinetics, and toxicology. You will drive advances in technology, infrastructure, and the use of informatics to accelerate drug discovery projects and improve probability of success. Finally, you will play a key role in staffing Treeline’s scientific software group by building an external reputation within the scientific community for excellence in computation applied to medicine discovery.
Watertown, MA; San Diego, CA; Remote.
- Design and develop robust data pipelines, and software tools, and drive advances in biological informatics to accelerate the data feedback loop in design-make-test-analyze cycles.
- Collaborate closely with computational biologists, scientific software engineers, and experimentalists to enable cross-domain data joins to facilitate answering questions across multiple data types, including genetic, ‘omics, assay, chemistry, macromolecular structure (protein/DNA/RNA), in vivo, etc.
- Design and implement features to export biological data into ELN.
- Collaborate with project teams to enable accurate data interpretation.
- Manage research software platforms: Raw data ingestion and curation workflows for simple to complex assay types, including high-throughput and high-content assays, data/metadata management, Cloud-based HPC.
- Support migration and integration of data and code into Treeline’s cloud-based platform.
- Contribute to the Treeline computational infrastructure by writing state-of-the-art software tools for drug discovery, mainly in Python.
- Work as a team member to troubleshoot and solve informatics issues.
- Bachelors or equivalent experience in Biology, Chemistry, Biological Data Science, Bioinformatics, or other STEM field, with 8+ years industry experience; or Ph.D. in one of these areas with 5+ years of industry experience.
- Experience with computation, data science or related area, as well as experience with multiple biological data types, especially in vitro screening data and macromolecular structure data.
- Strong scientific understanding of molecular biology, biochemistry, biophysics.
- Experience with software tools including Python, Java, pip, git, pandas, AWS, DevOps.
- Experience with LIMS, electronic laboratory notebooks (e.g. Signals), scientific data. management, compound registration, sample inventory, instrument data capture, conversion of raw assay data into analytics-ready form e.g. fitted curves.
- Experimental background or experience with biochemical or biophysical assays, enzymology, biology, and/or DMPK.
- Ability to dig deeply through various data types; demonstrated experience in pinpointing resolving incongruities between tools/frameworks.
- Proficient in data visualization.
- Excellent written and oral communication skills, including an ability to explain complex ideas to computational scientists, experimentalists, and clinicians.
- Capable of establishing strong working relationships across a distributed organization.
- Experience with scientific Python software such as: bioinformatics toolkits (Biopython); numpy/scipy/sklearn and chemistry toolkits (OEChem/RDKit).
- Experience with dashboard and visualization tools (e.g. Spotfire), management and monitoring of data pipelines at scale (e.g. Nextflow tower) and project management tools (e.g. Jira).
- Knowledge of human genetics and functional genomics.
Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)
The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.