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Principal Scientist, Medicinal Chemistry

at Treeline Biosciences (View all jobs)

Watertown, Massachusetts, United States

Principal Scientist, Medicinal Chemistry

About Treeline Biosciences

Treeline Biosciences is a new biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, structural biology, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

 

About you

You thrive in a fast-paced and matrixed discovery environment requiring scientific curiosity and rigor. With a drive to succeed, you are creative, diligent and meticulous in approaching difficult scientific challenges and collaborate across multiple disciplines to move programs forward. You have an eagerness to take on responsibilities outside of traditional medicinal chemistry roles to establish a new company.

 

About the role

The Principal Scientist of Medicinal Chemistry is primarily responsible for proposing, synthesizing, and characterizing small molecules as potential oncology therapeutics. The researcher will be accountable for collaborating with structural biologists, computational chemists, and other medicinal chemists to optimize the potency, pharmacokinetics, safety and in vivo efficacy of potential small molecule oncology drugs. A demonstrated track record of success in advancing clinical stage compounds enabled by structure-based design and in silico approaches is required.

 

Responsibilities

Basic Qualifications

Preferred Qualifications

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.

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