Research Associate / Senior Research Associate, Drug Discovery Biology
About the role
We are seeking an experienced, enthusiastic and highly motivated cell and molecular biologist to join our team. With a track record of contributing to multidisciplinary drug discovery teams, this position will play a critical role in driving Treeline’s portfolio forward. You will closely collaborate with other biologists, medicinal and computational chemists, structural biologists, biochemists, biophysicists, and data scientists to test therapeutic hypotheses and enable progress of drug discovery programs. You will also play a key role in the validation and selection of the next generation of oncology targets using cellular and molecular biology, biochemistry, genetics, functional genomics, and various state-of-the-art scientific approaches.
You thrive in a fast-paced and matrixed discovery environment requiring scientific curiosity and rigor. With a drive to succeed, you are self-motivated, innovative, detail-oriented, and a critical thinker who enjoys multidisciplinary collaborations to tackle difficult scientific challenges and move programs forward.
- Develop tool assets to advance drug discovery projects by establishing engineered cell lines using a variety of genetic tools.
- Execute a variety of cellular and molecular techniques to validate and characterize genetic or small molecule perturbations of targets and downstream pathways.
- Execute cell-based assay cascades to support drug discovery campaigns and mechanism of action studies.
- Design and conduct well controlled high-quality scientific experiments to test biological hypotheses.
- Contribute to evaluation and development of new approaches and technologies within the biology group.
- Maintain an electronic lab notebook in compliance with company policies.
- Help establish the biology group and contribute to building a culture that embraces continuous learning and improvement.
- BS or MS in biology, biochemistry, pharmacology or related discipline with at least 1-2 years of research experience in an academic or industry setting.
- Experience in mammalian cell culture, cell-based assays, mechanistic investigation using chemical and genetic tools, cell line engineering using RNAi and CRISPR.
- Experience with general molecular biological techniques, e.g. molecular cloning, qPCR, ELISA, MSD, proximity-based assays, Western blotting, immunoprecipitation.
- General knowledge of cancer signaling pathways, protein homeostasis, and regulation of gene expression.
- Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on cross-functional, multidisciplinary teams.
- Self-motivated individual wanting to work in a fast-paced and dynamic startup environment with the ability to multitask.
- Experience in developing/performing flow cytometry-based assays
- Knowledge and hands-on experience with oncology mouse models and in vivo pharmacology.
- Experience in small molecule drug discovery.
Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)
The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.